death-inducing signaling complex (DISC) -> complesso di segnalazione che induce la morte;

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iogo

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death-inducing signaling complex (DISC) -> complesso di segnalazione che induce la morte;

The death-inducing signaling complex or DISC is a multi-protein complex formed by members of the "death receptor" family of apoptosis-inducing cellular receptors. A typical example is FasR, which forms the DISC upon trimerization as a result of its ligand (FasL) binding. Dogma states that the DISC is composed of the death receptor, FADD, and caspase 8. It transduces a downstream signal cascade resulting in apoptosis.
Death-inducing signaling complex - Wikipedia, the free encyclopedia
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