ferroptosis -> σιδηρόπτωση


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ferroptosis -> σιδηρόπτωση

Ferroptosis is a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides, and is genetically and biochemically distinct from other forms of regulated cell death such as apoptosis. Ferroptosis is initiated by the failure of the glutathione-dependent antioxidant defenses, resulting in unchecked lipid peroxidation and eventual cell death. Lipophilic antioxidants and iron chelators can prevent ferroptotic cell death. Although the connection between lipid peroxidation has been appreciated for years, it was not until 2012 that Brent Stockwell and Scott Dixon coined the term ferroptosis and described several of its key features.


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